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When I quit, I knew I d never be back coaching. I knew I wouldn t be able to take it again. The pressures were so horrible. You know, the pressure of losing is bad, awful, because it kills you eventually. But the pressure of winning is worse, infinitely worse, because it keeps on torturing you and torturing you and torturing you. At Green Bay, I was winning one championship after another, after another, after another. I couldn t take it, because I blamed myself, damned myself, whenever they lost a game. I couldn t ever forgive myself for a loss, because I felt I d let them down. I felt I wouldn t be able to raise myself to the right pitch for the big games, and then I wouldn t be able to raise them to their best effort.

When a fan begins to wear out, it makes a whining or grinding noise. When this happens, replace the fan, unless it is inside the power supply. In that instance, replace the entire power supply. Opening the power supply is dangerous, and the time you d spend on such a repair is more valuable than the replacement cost of a power supply.

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POSKANZER DC, SCHAPIRA K, Miller H: Multiple sclerosis and poliomyelitis Lancet 2:917, 1963 PRINEAS JW: The etiology and pathogenesis of multiple sclerosis, in Vinken PJ, Bruyn GW (eds): Handbook of Clinical Neurology Vol 9 Amsterdam, North-Holland, 1970, pp 107 160 PRINEAS JW, BARNARD RO, KWON EE, et al: Multiple sclerosis: Remyelination of nascent lesions Ann Neurol 33:137, 1993 PRINEAS JW, CONNELL F: The ne structure of chronically active multiple sclerosis plaques Neurology 28:68, 1978 PRISMS STUDY GROUP: Randomized double-blind placebo-controlled study of interferon -1a in relapsing/remitting multiple sclerosis Lancet 352:1498, 1998 RAMIREZ-LASSEPAS M, TULLOCK JW, QUINONES MR, SNYDER BD: Acute radicular pain as a presenting symptom in multiple sclerosis Arch Neurol 49:255, 1992 RIZZO JF III, LESSELL S: Risk of developing multiple sclerosis after uncomplicated optic neuritis: A long-term prospective study Neurology 38: 185, 1988.

Signals that enter the cell (steroids, vitamin D, thyroid hormone, and retinoids) Signals that exert their effects from outside the cell (everything else) The signal is what starts everything off. Signals take a variety of forms, but for our purposes there are only two. The first type are signals that go into the cell, bind to internal receptors, and exert their effects. Steroid hormones, vitamin D, thyroid hormone, and retinoids are the only members of this class. All of the intracellular receptors ultimately activate the transcription of regulated genes. The common feature of signals that enter the cell is that they are all small lipophilic molecules that can cross the cell membrane. All the other signals exert their effects by binding to an extracellular receptor and initiating a cascade of signaling events. They work by activating a phosphorylation cascade and/or the release of second messengers in the cell.

RODRIQUEZ M, KARNES WE, BARTELSON JD, PINEDA AA: Plasmapheresis in acute episodes of fulminant in ammatory demyelination Neurology 43:1100, 1993 ROPPER AH, AYATA C, ADELMAN L: Vasculitis of the spinal cord Arch Neurol 2003 ROPPER AH, POSKANZER DC: The prognosis of acute and subacute transverse myelitis based on early signs and symptoms Ann Neurol 4:51, 1978 RUDICK RA, COHEN JA, WEINSTOCK-GUTTMAN B, et al: Management of multiple sclerosis N Engl J Med 337:1604, 1997 SADOVNICK AD, BAIRD PA, WARD RH: Multiple sclerosis: Updated risks for relatives Am J Med Genet 29:533, 1988 SADOVNICK AD, EBERS GC, DYMENT DA, et al: Evidence for a genetic basis for multiple sclerosis Lancet 347:1728, 1996 SCHAPIRA K, POSKANZER DC, MILLER H: Familial and conjugal multiple sclerosis Brain 86:315, 1963 SCHIFFER RB, SLATER RJ: Neuropsychiatric features of multiple sclerosis: Recognition and management Semin Neurol 5:127, 1985 SCHILDER P: Zur Kenntniss der sogennanten diffusen Sklerose.

Z Gesamte Neurol Psychiatry 10:1, 1912 SCHWARZ S, MOHR A, KNAUTH M, et al: Acute disseminated encephalomyelitis A follow-up study of 40 adult patients Neurology 56:1313, 2001 SELLEBJERG F, NIELSEN S, FREDERIKSON JL, et al: A randomized controlled trial of oral high-dose methylprednisolone in acute optic neuritis Neurology 52:1479, 1999 SHIRAKI H, OTANI S: Clinical and pathological features of rabies postvac-.

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